Research Paper Volume 15, Issue 15 pp 7673—7688

Emodin attenuates diabetic kidney disease by inhibiting ferroptosis via upregulating Nrf2 expression

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Figure 1. Ferroptosis induced pathological changes in DM rats. The mRNA expression of ferroptosis related indicators of renal tissues (AD). Immunohistochemical staining (E, 200× magnification) and semi-quantification analyses (F) of Col-I and Col-III in renal tissues of each group. The concentration of oxidant related indexes in renal tissues was measured (GJ). *P < 0.05, **P < 0.01 vs. normal group, #P < 0.05, ##P < 0.01 vs. model group.