Research Paper Volume 15, Issue 16 pp 7974—7996

Figure 3. Single cell analysis was performed on two datasets, GSE121636 and GSE171306. 24 clusters were identified using the UMAP method, and 14 cell types were identified, including lymphocytes (CD8+ T cells, B cells, NK cells, and CD4+ T cells), myeloid cells (monocytes, macrophages, neutrophils, DC cells, and mast cells), and other cells (endothelial cells, epithelial cells, plasma cells, and stem cells) (A-1 and A-2). An enrichment analysis for the cell components (A-3) was provided. The plots of cell components in the datasets of GSE121636 (A-4) and GSE171306 (A-5) were showed, respectively. The expression of CXCL genes was analyzed in lymphocyte and myeloid cells (B, C), and the correlation between CXCL genes and cell components was analyzed in a pan-cancer dataset, including CXCL genes and B cell (D-1), CXCL13 and T cell (D-2), CXCL genes and Macrophage (D-3), and CXCL genes and Neutrophil (D-4).