Research Paper Volume 15, Issue 16 pp 7974—7996

Figure 1. A plot showing the expression of CXCL genes in three datasets, TCGA-KIRC (A-1), GSE14762 (A-2), and GSE15641 (A-3). The expression of selected CXCL genes (CXCL 2/5/9/10/11) was upregulated in cancer tissues from the three datasets (A-4). In the TCGA-KIRC dataset, the OS and PFS of patients were analyzed. Selected CXCL genes (CXCL 1/2/3/5/8/13/14) were found to influence the prognosis of OS as shown in the forest plot (B-1). KM analysis was also performed on CXCL3 (B-2) and CXCL1 (B-3), with CXCL3 showing a P-value of 0.001 and CXCL1 showing a P-value of < 0.001. In the FPS analysis, CXCL 1/5/13 were associated with prognostic outcomes (C-1), and KM analysis was performed on CXCL1 and CXCL5, with CXCL1 showing a P-value of 0.005 and CXCL5 showing a P-value of < 0.001 (C-2, C-3).