Research Paper Volume 15, Issue 18 pp 9358—9376

Figure 3. Mutation genes, functional enrichment, tumor heterogeneity and stemness and TME. (A) waterfall plot showing top 10 differentially mutation genes between high- and low- SRLPI groups for prostate cancer patients in TCGA database; (B) lollipop plot showing the relationship between tumor stemness and heterogeneity indicators and SRLPI score in TCGA database; (C) heatmap showing differences of enriched hallmarks between high- and low- SRLPI groups in TCGA database; (D) heatmap showing differences of enriched pathways between high- and low- SRLPI groups in TCGA database; (E) lollipop plot showing the relationship between significant immune checkpoints and SRLPI score with correlation coefficient ≥0.3 in TCGA database; (F) lollipop plot showing the relationship between TME scores and SRLPI score in TCGA database. Abbreviations: SRLPI: senescence-related lncRNA prognostic index; TME: tumor immune microenvironment; TIDE: tumor immune dysfunction and exclusion; CAFs: cancer-associated fibroblasts; NK: nature killer. Note: prostate cancer patients were divided into high- and low- risk groups according to the median value of SRLPI score.