Research Paper Volume 15, Issue 11 pp 4949—4962
PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion
Figure 6. Altered expressions of PZR affect the phosphorylation of multiple proteins involved in cell adhesion and migration. Wild type (WT), PZR-knockout (PZR-KO), vector-overexpressing (V-OE), and PZR-overexpressing (PZR-OE) SPC-A1 cells were extracted in the RIPA buffer, and cells extract were subjected to Western blotting with the indicated antibodies. Note that knockout of PZR in SPC-A1 cells decreased phosphorylation of Src (Y416), FAK (Y397), and cortactin (Y421) (A) while overexpression of PZR had the opposite effects (B).