Research Paper Volume 15, Issue 11 pp 4794—4819

Figure 6. TMB analysis and Identification of potential compounds. (A, B) The waterfall plot of the mutation landscape of the top 15 genes with high mutation frequencies in the low- and high-risk groups. (C) TMB difference of patients in low- and high-risk groups. (D) Survival analysis for patients in high- and low-TMB. (E) Survival analysis for patients classified based on the TMB and 6-NRLs risk signature. The drug sensitivity of the high-risk group was higher than those of the low-risk group. (F) EHT.1864, Nutlin.3a, BIRB.0796, and PD.0332991. The drug sensitivity of the low-risk group was higher than those of the high-risk group. (G) BIBW2992, LFM.A13, WO2009093972, and Bosutinib.