Research Paper Volume 15, Issue 7 pp 2418—2432
Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats
Figure 4. Inflammatory cytokine secretion in the submandibular gland. Quantitative real-time PCR analysis of Il-6 (A) and Tnf-α (B) gene expression in the submandibular gland. The expression levels of Il-6 and Tnf-α mRNA were increased in the OVX group and decreased in the DFO and FER groups. Two-way ANOVA was performed. **p < 0.01, ***p < 0.001 vs. SHAM group, #p < 0.05, ##p < 0.01 vs. OVX group. Abbreviations: NS: not significant; SHAM: sham surgery group; OVX: ovariectomized group; DFO: deferoxamine injection group; FER: ferrostatin-1 injection group; Il-6: interleukin 6; Tnf-α: tumor necrosis factor-alpha.