Research Paper Volume 15, Issue 6 pp 1977—2004
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice
Figure 4. Hsp22 levels were increased in hippocampus tissue after LPS stimulation and increased expression after Hsp22 pretreatment. (A, B) Immunohistochemical staining images of Hsp22(*p < 0.05 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; #p < 0.05 vs. LPS). (C) The protein band of Hsp22 and its expression (*p < 0.05 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; #p < 0.05 vs. LPS+Lv-Hsp22-NC). (D) The protein band of TNF-α and its expression (*p < 0.05 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; #p < 0.05 vs. LPS+Lv-Hsp22-NC).