Research Paper Volume 15, Issue 5 pp 1668—1684
Identification and validation of eight estrogen-related genes for predicting prognosis of papillary thyroid cancer
Figure 7. The top 6 significantly enriched pathways in the high-risk and low-risk groups. GSEA identified six pathways significantly enriched in the high-risk group, including E2F target (A), G2M checkpoint (B), epithelial-mesenchymal transition (C), IL6/JAK/STAT3 signaling (D), KRAS signaling (E), and IL2/STAT5 signaling (F) (All p < 0.01). (G) Western blots of KRAS signaling in TPC-1 and KTC-1 cells with and without NMU knockdown. GAPDH was used as the loading control, p-AKT and p-ERK levels were significantly lower with NMU knockdown.