Research Paper Volume 15, Issue 5 pp 1591—1602
The disturbance of thyroid-associated hormone and its receptors in brain and blood circulation existed in the early stage of mouse model of Alzheimer’s disease
Figure 3. Expression of thyroid hormone receptor gene in the hippocampus of mice. The results of real-time quantitative PCR showed that the expression of thyroid receptor gene THRα (A) and THR β (B) was higher in the okadaic acid (OA) treated group than that in the control group at 2 weeks after injection (****P < 0.001), however, there was no significant difference in thyroid receptor gene expression between the control group and the normal group (P = 0.650 and 0.924, respectively). Normal: Mice without stereotactic puncture; control: The mice were punctured stereotaxically and injected with 5 μL of normal saline; OA: Mice were subjected to stereotactic puncture and injection of 5 μL of 0.1 μM okadaic acid. (LSD test, n = 6).