Research Paper Volume 15, Issue 5 pp 1279—1305
Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue
Figure 4. IL-6 production induced by proinflammatory cytokines and bacterial pathogens in senescent HPDL cells. (A) Relative mRNA expression of IL-6 stimulated by IL-1β (1 ng/ml) and P.g LPS (1 μg/ml) in YPDLs and APDLs quantified by qRT-PCR (*p < 0.01). (B) IL-6 and IL-8 in conditioned medium of YPDLs and APDLs quantified by ELISA (*p < 0.01). Representative data from three experiments are shown.