Figure 4. Validation of the prognostic signature. Validation of the prognostic signature in the external datasets (A) GSE41271 and (B) GSE31210. DCA curve was used to assess the clinical utility of the prognostic signature associated with CRFGs versus a single cuproptosis or ferroptosis model at (C) 1 year, (D) 3 years, and (E) 5 years of OS. Model1 represents the CRFGs-related model, Model2 represents the cuproptosis-related model, and Model3 represents the ferroptosis-related model.