Research Paper Volume 15, Issue 4 pp 932—946
Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice
Figure 3. Effects of AMPKα isoform reduction on spatial learning and memory in aged mice. (A) The training phase of the hidden platform Morris water maze (MWM) test showed day-to-day escape latency of the mice. n=14 for Cre+/-, n=15 for AMPKα1 cKO and AMPKα2 cKO. p=0.78 (interaction between groups). Two-way ANOVA. (B) Escape latency on day 3 of the MWM test. *p<0.05. One-way ANOVA and Tukey’s test. (C) Measurement of the target quadrant occupancy in the probe trial phase of the MWM test, n=14 for Cre+/-, n=15 for AMPKα1 cKO and AMPKα2 cKO. p=0.056, One-way ANOVA. (D) Visible platform test. n=11-15 mice per group. p>0.05 One-way ANOVA.