Figure 3.Effects of AMPKα isoform reduction on spatial learning and memory in aged mice. (A) The training phase of the hidden platform Morris water maze (MWM) test showed day-to-day escape latency of the mice. n=14 for Cre+/-, n=15 for AMPKα1 cKO and AMPKα2 cKO. p=0.78 (interaction between groups). Two-way ANOVA. (B) Escape latency on day 3 of the MWM test. *p<0.05. One-way ANOVA and Tukey’s test. (C) Measurement of the target quadrant occupancy in the probe trial phase of the MWM test, n=14 for Cre+/-, n=15 for AMPKα1 cKO and AMPKα2 cKO. p=0.056, One-way ANOVA. (D) Visible platform test. n=11-15 mice per group. p>0.05 One-way ANOVA.
