Research Paper Volume 15, Issue 5 pp 1257—1278
Age-related methylation changes in the human sperm epigenome
Figure 3. Chromosomal distribution of human sperm ageDMRs. The upper panel shows a Manhattan plot of 360,264 regions analysed by RRBS. 1,565 (0.4%) regions above the red line are endowed with genome-wide significant ageDMRs. The bottom plot shows the chromosomal distribution of the 1,565 ageDMRs (orange bars), compared to the 358,699 other (non-significant) regions (blue bars). The y-axis represents the percentage of ageDMRs and other regions, respectively, on each chromosome. AgeDMRs are significantly overrepresented on chromosome 19, and depleted on chromosomes 6, 10, and 21.