Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice

Jun Yan; Te Liu; Yang Li; Jun Zhang; Bo Shi; Fuqiang Zhang; Xuejia Hou; Xiaowen Zhang; Wanxing Cui; Jing Li; Hua Yao; Xiuying Li; Yufei Gao; Jinlan Jiang

doi:doi:10.18632/aging.204540

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Research Paper Volume 15, Issue 4 pp 1130—1142

Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice

Figure 2. Characterization of human umbilical cord mesenchymal stem cells (HUMSCs) labeled or not with polydopamine-capped Fe₃O₄ nanoparticles (MIONs@PDA). (A) Similar to normal HUMSCs, MIONs@PDA-MSCs highly expressed the typical surface markers CD44 and CD90, but not the hematopoietic cell marker CD45. (B) Osteocyte and adipocyte differentiation of MIONs@PDA-MSCs vs. control HUMSCs. All cells exhibited adipogenic and osteogenic differentiation potential similar to that of control HUMSCs. Scale bars = 50 μm.