Research Paper Volume 15, Issue 4 pp 1039—1051
RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma
Figure 5. Patients with RIOK3 and Treg cell positivity have a worse prognosis. (A) Representative IHC staining of CD3, CD4, CD8, and FOXP3 in PDAC tissues (n=46). The cut-off value of immune cells was median. (B) The association between RIOK3 expression and the number of CD3, CD4, CD8, and FOXP3 cells in PDAC (|r|>0.2 and p<0.05). R represents the Pearson correlation coefficient. (C) Kaplan–Meier curves of DFS and OS analysis according to RIOK3 and Treg cell levels in PDAC patients (n=46, 16 RIOK3-high+Treg-high and 30 others).