Research Paper Volume 15, Issue 4 pp 1039—1051

Figure 1. RIOK3 protein is highly expressed in PDAC tissues and associated with poor prognosis. (A) ROC curve of RIOK3 mRNA for prediction PDAC in TCGA and GTEx datasets (AUC=0.954, 95%CI:0.921-0.969) (n=350, 171 Normal and 179 Tumor). (B) Representative IHC staining of RIOK3 and IHC analysis of RIOK3 expression in PDAC and paired adjacent normal tissue (n=46; p=0.004). Paired samples Wilcoxon test. (C) Representative IHC staining of RIOK3 and IHC Immunohistochemical analysis of RIOK3 expression in different stages of PDAC tissues (n=46; 15 Stage I, 21 Stage II, 3 Stage III, and 7 Stage IV; F = 17.331, P < 0.001). One-way ANOVA test. (D) Kaplan–Meier curves of DFS and OS analysis of RIOK3 expression in PDAC patients (n=46, 28 high-RIOK3 and 18 low-RIOK3). The star (*) symbol denotes the level of statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001, ns no significance.