Research Paper Volume 15, Issue 6 pp 1713—1733
Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells
Figure 5. Transcriptome profiling of POLDIP2 knockout in ARPE-19. (A) Heatmap of top 50 DE genes detected in WT (n=3) and POLDIP2 KO (n=3) cell lines. (B) Boxplot of the expression levels of RPE markers BEST1, RDH5, RDH10, and PMEL in different samples. (C) Volcano plot of the top 20 DE genes labelled in POLDIP2 KO cell lines (n=3). (D) GO annotation of the top 50 up-regulated DE genes in POLDIP2 KO samples (n=3). (E) Network topology of the top up-regulated DE genes in POLDIP2 KO samples (n=3).