Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice

Yukiko Kitase; Julian A. Vallejo; Sarah L. Dallas; Yixia Xie; Mark Dallas; LeAnn Tiede-Lewis; David Moore; Anthony Meljanac; Corrine Kumar; Carrie Zhao; Jennifer Rosser; Marco Brotto; Mark L. Johnson; Ziyue Liu; Michael J. Wacker; Lynda Bonewald

doi:doi:10.18632/aging.204390

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Research Paper Volume 15, Issue 2 pp 308—352

Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice

Figure 9. Aging effects on femoral cortical parameters. Aging effects were observed in BV/TV in LBW and HBW subgroups of 22 mo CTRL mice, Co.Th and Co.Area in 22 mo CTRL/HBW, BV/TV and BMD in LBW and HBW of 22 mo VWR mice, Pe.Cir and En.Cir in 22 mo VWR/HBW mice. Femoral cortical bone parameters, (A) bone volume fraction BV/TV, (B) bone mineral density BMD, (C) cortical thickness Co.Th, (D) cortical area Co.Area, (E) periosteal circumference Pe.Cir., and (F) endosteal circumference En.Cir, were measured by microCT. ^*: p < 0.05, ^**: p < 0.01, and ^***: p < 0.001, 22 mo vs. 18 mo mice. Abbreviations: CTRL: control group; VWR: voluntary wheel running group; CBW: Combined groups (18 mo: n = 16 CTRL, n = 17 VWR; 22 mo: n = 8 CTRL, n = 8 VWR); LBW: Low body weight group (18 mo: n = 8 CTRL, n = 10 VWR; 22 mo: n = 4 CTRL, n = 4 VWR); HBW: High body weight group (18 mo: n = 8 CTRL, n = 7 VWR; 22 mo: n = 4 CTRL, n = 4 VWR).