Research Paper Volume 15, Issue 2 pp 308—352
Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice
Figure 7. Maintenance of skeletal muscle-secreted osteocyte protective factors by long-term voluntary wheel running in aged LBW mice. Endurance exercise restored skeletal muscle-secreted osteocyte protective factors in aged 18 mo and 22 mo old LBW, but not HBW mice. (A, B) The effect of VWR on osteocyte protective factors in each skeletal muscle CM under ex vivo static and contracted conditions obtained from two different subgroups, LBW and HBW mice. (A) 18 mo and (B) 22 mo mice. *: p < 0.05, and **: p < 0.01, VWR vs. CTRL mice. Abbreviations: CTRL: control group; VWR: voluntary wheel running group; CBW: Combined groups (18 mo: n = 16 CTRL, n = 17 VWR; 22 mo: n = 8 CTRL, n = 8 VWR); LBW: Low body weight group (18 mo: n = 8 CTRL, n = 10 VWR; 22 mo: n = 4 CTRL, n = 4 VWR); HBW: High body weight group (18 mo: n = 8 CTRL, n = 7 VWR; 22 mo: n = 4 CTRL, n = 4 VWR).