Research Paper Volume 14, Issue 23 pp 9445—9457

Figure 1. Micro-array analysis of genes expression in Lmna^Dhe/+ mutant MSCs compared to normal MSCs. Gene expression was analyzed by a microarray using an antibody. (A) Antibody microarray assay (Ray L1000 Antibody Array) can analyze 1000 genes and has 15 domains such as inflammatory response, neurogenesis, RNA splicing, secretion, extracellular matrix, angiogenesis, cell cycle, apoptotic processes, cell differentiation, cell death, cell migration, cell proliferation, DNA repair, aging, and immune response. (B) We analyzed the differences in gene expression in Lmna^Dhe/+ mutant MSC compared to normal MSC. (C) Decreases of osteogenesis-related genes expression in Lmna^Dhe/+ mutant MSCs compared to normal MSCs.