Research Paper Volume 14, Issue 19 pp 8032—8045
SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3
Figure 1. SENP3 protein level correlates with protein expression of STAT3 and p-STAT3 in bladder cancer. (A) Differences of STAT3 between bladder cancer tissues and adjacent normal tissues, determined by bioinformatics analysis. (B) Disease free survival with low and high STAT3 TPM. (C) SENP3 level between bladder cancer tissues and adjacent normal tissues, determined by bioinformatics analysis. (D) The probability of cancer progression plotted over a period of 150 months for patients with high or low SENP3 expressions. (E) SENP3, STAT3 and p-STAT3 protein levels in bladder cancer tissues and adjacent normal tissues, as measured by western blot. (F) Expression of STAT3 and p-STAT3 in bladder cancer tissues and adjacent normal tissues by immunohistochemistry [scale bar, 50 μm]. (G) SENP3, STAT3 and p-STAT3 protein levels in 5637, T24, J82, EJ, RT4 and SV-huv-1 cells.