Research Paper Volume 14, Issue 19 pp 7959—7971
APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6
Figure 6. Enhancing of the expression of MAP2K6 attenuates the anti-oncogenic effect of silencing of APEX1. (A) The positive correlation between APEX1 expression and MAP2K6 expression in HCC tissues. (B–D) Cell vitality was evaluated with CCK-8 (B), colony formation (C) and EdU assay (D) assays in HCC cells. (E, F) Wound healing (E) and Transwell (F) assays were performed to evaluate the migration and invasion abilities of the HCC cells. (G, H) Flow cytometry was performed to evaluate apoptosis (G) and cell cycle distribution (H). *P < 0.05.