Research Paper Volume 14, Issue 17 pp 7170—7185
A circadian rhythm-related gene signature for predicting relapse risk and immunotherapeutic effect in prostate adenocarcinoma
Figure 9. The effects of CR-related risk score on response to ICIs. (A) MSI levels was elevated in the high-risk patients than in low-risk patients (P <0.001). (B) MSI levels were positively correlated with risk score (P < 0.05, R = 0.37). (C) Risk score was significantly increased in MSI-H group than MSI-L/MSS group (data of MSI generated from PreMSIm R package; P < 0.001). (D) Risk score was significantly higher in MSI-H group than MSI-L/MSS group (data of MSI generated from UCSCXenaShiny R package; P < 0.05). (E) Comparison of multiple immune checkpoint mRNA (PDCD1, LAG3, CD40, CTLA4, PDCD1LG2) in the high-risk patients and the low-risk patients. *P <0.05, ** P <0.01, ***P<0.001.