Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

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Figure 7. Effect of GQ and miRNA on the expression of P-gp in tumor tissues. (A) P-gp expression levels in tumor tissues were detected by IHC assay, the bar indicated 100 μm; (B) Quantitative analysis of the results in (A); (C) P-gp expression levels in tumor tissues were detected by western blot. All data represent the means ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, comparing with control group. #P < 0.05, ##P < 0.01, ###P < 0.001, comparing with miR-451, GQ and ADR combination group.