Combination of 7-<i>O</i>-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

Yuling Chen; Xiaohong Li; Lei Shi; Pengfei Ma; Wei Wang; Nan Wu; Youlin Gan; Xu Han; Shanshan Huang; Xiaohui Kang; Shuxin Liu; Yuhong Zhen

doi:doi:10.18632/aging.204287

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Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

Figure 4. Effect of GQ and miR-451 on the migration inhibition of ADR to MCF-7/ADR cells. MCF-7/ADR cells or miR-451-transfected MCF-7/ADR cells were seeded on 6-well plates with monolayer and divided on average with a UV-sterilized ruler and pipette tips. Then the cells were treated with GQ (10 μM), ADR (43 μM) or their combination for 48 h and photographed using an inverted microscope.