Combination of 7-<i>O</i>-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

Yuling Chen; Xiaohong Li; Lei Shi; Pengfei Ma; Wei Wang; Nan Wu; Youlin Gan; Xu Han; Shanshan Huang; Xiaohui Kang; Shuxin Liu; Yuhong Zhen

doi:doi:10.18632/aging.204287

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Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

Figure 3. MiRNAs regulated the expression of MRP1, BCRP and P-gp proteins. (A) Western blot was conducted to detect the expression of MRP1, BCRP, P-gp and β-actin in MCF-7/ADR cells and MCF-7/ADR cells transfected with miRNAs. (B) Quantitative analysis of the results in (A). All data represent the means ± SD of three independent experiments. ^*P < 0.05, ^***P < 0.001, comparing with control group.