Combination of 7-<i>O</i>-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

Yuling Chen; Xiaohong Li; Lei Shi; Pengfei Ma; Wei Wang; Nan Wu; Youlin Gan; Xu Han; Shanshan Huang; Xiaohui Kang; Shuxin Liu; Yuhong Zhen

doi:doi:10.18632/aging.204287

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Research Paper Volume 14, Issue 17 pp 7156—7169

Combination of 7-O-geranylquercetin and microRNA-451 enhances antitumor effect of Adriamycin by reserving P-gp-mediated drug resistance in breast cancer

Figure 1. MiRNAs reversed ADR-resistance in MCF-7/ADR cells. (A) Expression of miR-326, miR-328, miR-451 and miR-155 in MCF-7 and MCF-7/ADR cells were detected by Real-time RT-PCR. ^***P < 0.001, comparing with MCF-7 cells. (B) MCF-7/ADR cells and MCF-7/ADR cells transfected with miRNAs were treated with ADR (43 μM) for 48 h. Cell viability was measured by CCK-8 assay. All data represent the means ± SD of three independent experiments. ^**P < 0.01, ^***P < 0.001, comparing with non-transfection group.