Research Paper Volume 14, Issue 17 pp 7126—7136
Zbtb34 promotes embryonic stem cell proliferation by elongating telomere length
Figure 5. Zbtb34 competes for the binding sites on telomeres with Pot1b. (A) Schemata represents the Myc-Pot1a and Flag-Pot1b constructs. (B) Telomere co-immunoprecipitation shows the association of Zbtb34 and Pot1a or Pot1b with telomere DNA in mESCs. The random sequence (TGTGAG) is the control. Abbreviations: ZnF: zinc finger; OB: oligonucleotide binding; HJR: holiday junction resolvase; mESCs: mouse embryonic stem cells.