Figure 4. Increased mRNA expression of UCP-1 in brown adipose tissue of 3 months old SAMP8 mice. Data are mean ± SEM, analyzed by 2-way ANOVA with Bonferroni post test. Significance is *P < 0.05, and ***P < 0.001; *SAMP8 mice compared to SAMR1, +age-dependent changes in SAMR1, and # age-dependent changes in SAMP8. n = 4-5 mice per group.