Figure 4. The left half of figure shows 6-OHDA induced cytological changes and iron deposition, it shows that 6-OHDA can induce dopamine neuron apoptosis, glial cell activation, and the expression of many transferrin on cell membrane, which can specifically induce iron ion to be transported from blood to brain cells and stored, leading to iron deposition in SNpc. The right half shows FA and T2* mapping images. The T2WI image in the middle is the reference image for measuring FA and T2* values, and the small red circle in the figure is the position of the ROI.