Figure 4. The expression of hub genes and transcription factor (TF) regulatory network in the critical module. (A) The expression heatmap of hub gene. (B) The interaction regulatory network of TF and target genes. The core circles are two transcription factors (CDC5L and HMGB2). The surrounding circles represent their target genes, the color represents the source module, the circle size represents the expression, and the yellow circle represents the hub gene.