Research Paper Volume 14, Issue 17 pp 7052—7064
Bruton tyrosine kinase (BTK) may be a potential therapeutic target for interstitial cystitis/bladder pain syndrome
Figure 4. Differential expression of BTK in IC/BPS clinical samples. (A) HE staining shows the pathological state of IC/BPS samples. Scale bar: 100 and 50 μm. (B) Masson staining is used to distinguish collagen fibers from muscle fibers. Collagen fibers are blue and smooth muscle fibers are red. The staining results show that compared with NC group, collagen fibers in IC/BPS group are significantly reduced. Scale bar: 100 and 50 μm. (C, D) IHC staining showed the difference of (C) Tryptase and (D) BTK expression in normal and IC/BPS tissues. Scale bar: 20 μm. (E) Western blotting exhibited the expression level of BTK in normal and IC/BPS tissues. In all cases, Values are mean ± SD (n=10 for each group; *P<0.05, **P<0.01).