Research Paper Volume 14, Issue 17 pp 6887—6904

Figure 3. Hormone levels in the plasma of female offspring rats exposed to ACR during their fetal life compared to those in controls. (A) Plasma progesterone levels (ng/mL) in AF1 significantly increased in 2.5 and 20 mg/kg/day doses compared to the control group, while the increase in 10 mg/kg/day dose was nonsignificant. (B) Plasma progesterone levels (ng/mL) in AF2 were significantly elevated in all ACR dose (2.5, 10, and 20 mg/kg/day) groups compared to that in the control group CF2. (C) Plasma estradiol levels in AF1 groups recorded a high significant decrease in all doses of ACR. (D) A Plasma estradiol levels significantly increased in all AF2 treated groups compared to the control group CF2. (E) Plasma IGF-1 levels significantly decreased in all treated groups of AF1 compared to the control group. (F) We found a significant increase in plasma IGF-1 levels in the AF2 group treated with 10 mg/kg/day, whereas no significant variation was found in 2.5 and 20 mg/kg/day groups compared to the control group CF2. (G) Plasma testosterone levels in AF1 groups show a significant decline in 2.5 mg/kg/day and 20 mg/kg/day, whereas no significant variation was noted in 10 mg/kg/day. (H) No significant changes were observed in plasma testosterone levels in all AF2 treated groups compared to the control group CF2.