Integrated PPI- and WGCNA-retrieval of hub gene signatures for soft substrates inhibition of human fibroblasts proliferation and differentiation

Ziran Xu; Tian Zhou; Yin Wang; Leijie Zhu; Jihao Tu; Zhixiang Xu; Lisha Li; Yulin Li

doi:doi:10.18632/aging.204258

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Research Paper Volume 14, Issue 17 pp 6957—6974

Integrated PPI- and WGCNA-retrieval of hub gene signatures for soft substrates inhibition of human fibroblasts proliferation and differentiation

Figure 2. Differential expression analysis of soft/TCP. (A) Venn diagram of soft and TCP. (B) Scatter plot illustrated DEGs of soft/TCP. (C) Heat-map cluster analysis of DEGs. (D) KEGG pathways of up and down regulated DEGs. The color and horizontal axe were −log₁₀ (p value) and gene number respectively. (E) GO analysis of up- and down- regulated DEGs. The GO analysis categorized mRNA into different groups: BP, CC, and MF. The color and horizontal axe were −log₁₀ (p value) and gene number respectively.