Research Paper
Senescent phenotype of astrocytes leads to microglia activation and neuronal death
Figure 1. Age related cognitive impairment and neuron loss in mice. (A) Escape latency. (B) Movement Trajectory of mice. (C) Frequency through platform. (D) Latency to platform location. (E) The average swimming speed. (F) The percentage of time in target quadrant. (G) The percentage of path length in target quadrant. (H) HE staining of mouse brain. Scale bar, 50 μm. (I) Nissl staining in the hippocampus of each group. Scale bar, 50 μm. (J) The number of living neurons of hippocampus in mice. All experiments were expressed as the mean +/−S.D, analyzed by ANOVA followed by Tukey’s test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.