Figure 8. SPIB-related gene enrichment and pathway analysis. (A) SPIB protein network map based on STRING database. (B) GO analysis of the top 100 genes associated with SPIB expression. (C) KEGG analysis of the top 100 genes associated with SPIB expression. (D) Correlation between the most relevant genes for SPIB expression, including PEZ1, GNA12, MAP4, SEPT7 TPST1, and TBL2 of the GEPIA2 tool. (E) Heatmap of genes significantly associated with SPIB expression.