Research Paper Volume 14, Issue 18 pp 7364—7377
M1 macrophage-derived exosomes synergistically enhance the anti- bladder cancer effect of gemcitabine
Figure 6. Effect of M1-Exo-GEM on tumor apoptosis in tumor-bearing mice. (A) In IHC staining, Caspase-3 and Bax were negatively expressed in the Control group. In the M1-Exo and GEM groups, these expressions were significantly up-regulated, where pathological changes of tissue damage occurred. In the M1-Exo-GEM group, Caspase-3 and Bax expressions were significantly up-regulated, showing higher levels than those in the M1-Exo and GEM groups. (B) PHK-67 tracing of Exos revealed enrichment of M1-Exo-GEM in tumor tissues, indicating that tumor tissues could take up Exos.