Research Paper Volume 14, Issue 18 pp 7364—7377

Figure 5. Effect of M1-Exo-GEM on tumor-bearing mice. (A) M1-Exo-GEM could inhibit the tumor growth, as manifested by significantly lower tumor volume than that in the M1-Exo and GEM groups. *P<0.05 vs. Control group. (B) In H&E staining, obvious inflammation and edema-like lesions appeared in the M1-Exo and GEM groups, as well as damage of tissues. In the M1-Exo-GEM group, tissue necrosis occurred, and tumor cells were obviously damaged. (C) In TUNEL staining, no apparently damaged cells were found in the Control group, which were TUNEL-negative. Obvious cell damage occurred in the M1-Exo and GEM groups. M1-Exo-GEM group exhibited significantly higher number of TUNEL-positive cells than that in the M1-Exo and GEM groups.