Research Paper Volume 14, Issue 18 pp 7364—7377

Figure 2. Cytotoxicity of M1-Exo-GEM against MB49. (A, B) FCM found that M1-Exo and GEM could induce apoptosis, and M1-Exo-GEM could further increase the apoptosis rate significantly than M1-Exo and GEM, **P<0.05. (C) Cell viability assay revealed that M1-Exo and GEM could inhibit cell viability in a time-dependent manner. In M1-Exo-GEM group, the cell viability was further reduced, which was lower than that in M1-Exo and GEM groups, *P<0.05 vs. Control group. (D–F) In the inflammatory cytokine detection, M1-Exo and GEM could promote the expressions of TNF-α, IL-6 and IL-1β, as manifested by significantly higher levels than those in the Control group, while the M1-Exo-GEM group exhibited higher levels of inflammatory cytokines than those in the M1-Exo and GEM groups. *P<0.05 vs. Control group.