Research Paper Volume 14, Issue 15 pp 6094—6110
miRNA-338-3p inhibits the migration, invasion and proliferation of human lung adenocarcinoma cells by targeting MAP3K2
Figure 5. Functional verification of miR-338-3p/MAP3K2 axis in NCI-H1299 and A549 cells. (A) the effect of miR-338-3p on MAP3K2 transcription was identified by luciferase reporter assay in HCI-H1299 and A549 cells, and the putative wild-type MAP3K2 3'-UTR binding sequence as well as the mutation sequence. (B) Statistical results of protein expressions in NCI-H1299 and A549 cells. **P < 0.01 means that the difference is statistically significant. (C) Protein expressions of MAP3K2, p-ERK1/2 and t-ERK1/2 in A549 cells. **P < 0.01 means that the difference is statistically significant.