Research Paper Volume 14, Issue 15 pp 6094—6110
miRNA-338-3p inhibits the migration, invasion and proliferation of human lung adenocarcinoma cells by targeting MAP3K2
Figure 4. The relationship of miR-338-3p with MAP3K2 in human specimens. (A) Human lung adenocarcinoma and pericancerous tissue were identified by HE staining. (B) The statistical decreased expression of miR-338-3p in adenocarcinoma than pericancerous. **P < 0.01 means that the difference is statistically significant. (C) The relative miR-338-3p levels in 4 cell lines after transfected with miR-338-3p NC, mimic, inhibitor. **P < 0.01 means that the difference is statistically significant. (D) miR-338-3p mimic decreased the MAP3K2 protein levels, and miR-338-3p inhibitor increased the MAP3K2 protein levels in human adenocarcinoma cell lines: NCI-H1299 and A549 cells but not Calu-3 cells. **P < 0.01 vs. Calu-3 group, means that the difference is statistically significant.