Research Paper Volume 14, Issue 13 pp 5511—5522
Detachment stress mediated bioenergetic switch of malignant melanoma cells into anti-Warburg phenotype
Figure 5. Detachment stress altered the drug sensitivities toward the blockades of glycolysis and mitochondrial respiration in different melanoma cells. Suspended melanoma cells were less sensitive to treatment of 2DG, but more sensitive to treatment of rotenone in (A) melanoma A375 cells and (B) melanoma A2058 cells. Data were mean ±S.D. (n=6).