Research Paper Volume 14, Issue 13 pp 5390—5405
MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription
Figure 8. Molecular mechanism diagram. The transcription factor SPI1 binds to the TMEFF1 promoter region to promote the transcription of TMEFF1. Overexpression of MIR503HG can bind to SPI1, block the transcriptional activation of TMEFF1 by SPI1, and inhibit the expression level of TMEFF1, thereby hindering the progression of ovarian cancer.