Research Paper Volume 14, Issue 11 pp 4786—4818
Identification of prognostic candidate signatures by systematically revealing transcriptome characteristics in lung adenocarcinoma with differing tumor microenvironment immune phenotypes
Figure 3. Mutation landscape of the TME immune phenotype. (A) Main mutant genes in the high immune infiltration group. TP53, TTN, MUC16, CSMD3 and RYR2 are the main mutant genes. (B) Main mutant genes in the low immune infiltration group. TTN, TP53, CSMD3, MUC16 and RYR2 are the main mutant genes. (C) The expressions of the top five mutant genes between LUAD and normal tissues. The expressions of five genes had significant differences between LUAD and normal tissues. (D) The expression correlations among the top five mutant genes. The correlations among the top five mutant genes were low in expressions. (E) The expressions of the top five mutant genes between the high and low immune infiltration groups. The expression of RYR2 gene had significant difference between two groups. (F) The expression correlations of the top five mutant genes in two immune infiltration groups. The correlations among the top five mutant genes were low in expressions. (G) The associations of the top five mutant genes with clinical features in the TME immune phenotype. The expressions of these genes were significantly associated with T stage and age. TME, tumor microenvironment; LUAD, lung adenocarcinoma.