Research Paper Volume 14, Issue 11 pp 4634—4652

Figure 2. The effects of NYT on the electrophysiological properties of MSNs in the NAc core subregion. (A) The protocol of positive current injections (50 pA increments from 0 to 400 pA, 250 msec) and the representative membrane potential recordings obtained by 200 pA current injection. The relationship of (B) firing frequency, (C) first spike latency and (D) interspike interval obtained by positive current injections (n = 11 from seven mice). (E) The protocol of negative current injections (50 pA increments from -800 to 0 pA, 250 msec) and the representative membrane potential recordings obtained by negative current injections. (F) The I-V relationship obtained by negative current injections (n = 11 from seven mice). (G) The input resistance in -800 pA (left) and -200 pA (right) current injections (n = 11 from seven mice). (H) The resting membrane potential (n = 9 from seven mice). (I) The protocol of voltage pulses (10 mV increments from -70 to -40 mV, 100 msec, holding potential = -70 mV) and the representative current recordings obtained by voltage pulses. (J) The I-V relationship obtained by voltage pulses (n = 5 from two mice). Error bars are expressed as mean ± SEM. Statistical analyses were performed by one-way or two-way RM ANOVA followed by Dunnett’s multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001; Baseline vs. NYT, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001; NYT vs. Washout. The arrows indicate the time points of analysis.