Research Paper Volume 14, Issue 11 pp 4714—4727
TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction
Figure 6. TLR3 deletion inhibited activation of TRIF and degradation of SHP2 and down-regulated expressions of TLR signaling pathway-related proteins. (A) Expressions of TLR3, p-TRIF and SHP2 in the hippocampus of neonatal mice. (B) Expressions of p-RIP3 and CaMKII in the hippocampus of neonatal mice. (C) Expressions of NLRP3, GSDMD, Caspase-1, Caspase-4 and Caspase-11 in the hippocampus of neonatal mice. **p < 0.01, and *p < 0.05.