Research Paper Volume 14, Issue 9 pp 4036—4049

Figure 2. PTX3 KD improved the cardiac functions in murine HF after MI. (A) Electrocardiogram results confirmed that the animal model was successfully constructed. (B) Representative M-mode echocardiogram of LV in the parasternal short-axis view obtained from mice in each group. Echocardiographic parameters (LVAWd, LVAWs, LVIDd, LVIDs, ES and FS as well as E peak rate, A peak rate, PVA, PVD, PVS) at three cardiac cycles were recorded. LVAWd: left ventricular anterior wall thickness at end-diastolic; LVAWs: left ventricular anterior wall thickness at end-systolic; LVIDd: left ventricular internal diameter at end-diastolic; LVIDs: left ventricular internal diameter at end-systolic; EF: ejection fraction; FS: fraction shortening; PVD: Positive peak velocity of pulmonary vein in diastole; PVS: Peak systolic velocity of pulmonary vein; PVA: Negative peak velocity of pulmonary vein during atrial contraction. Control group vs. PTX3-NC group, *p<0.05, ** p<0.01; PTX3-NC group vs. PTX3-KD group, ^# p<0.05, ^## p<0.01.