Research Paper Volume 14, Issue 7 pp 3143—3154

Figure 6. The relationship between the expression of lncMIAT/miR-216a and p38MAPK in PBMCs. (A) The comparison of miR-216a levels in PBMCs was performed between osteoporosis patients and healthy participants, which was detected by RT-qPCR analysis. (B) The miR-216a expression levels were compared between low lncMIAT and high lncMIAT groups. (C) The plasma concentration of IL-6 and TNF-α was compared between lncMIAT high and low expression group in our cohort. Totally 32 post-menopausal patients with complete test results were collected for the analysis. (D) Linear regression model was used for the correlation of lncMIAT and p38MAPK expression in PBMCs from osteoporosis patients. *, p < 0.05. (E) A graphic summary for LncMIAT contributing to proinflammatory cytokine secretion in post-menopausal osteoporosis.