Research Paper Volume 14, Issue 7 pp 3105—3128

Figure 6. Xenograft experiments in female nude mice with circ_6014 knockdown. (A) Expression level of circ_6014 in stable circ_6014 knockdown MDA-MB-231 cells. (B) Photo of individual tumors. (C) The size of tumors of each group varied with time, and that of the experimental group was smaller. (D) The comparison of the tumor weight between the circ_6014 knockdown group and the negative control group and that of the experimental group was lighter. (E) The weight of the mice in the two groups varied with time. (F) The expression level of miR-885-3p increased in individual tumors of the stable circ_6014 knockdown mice compared with those of the negative control mice. (G) The expression level of NTRK2 decreased in individual tumors of the stable circ_6014 knockdown mice compared with the negative control mice. (H) Protein levels of NTRK2, PIK3CA, p-AKT, and AKT in individual tumors of the stable circ_6014 knockdown or negative control mice. (I) Quantitative statistics of protein expression levels in the two groups of mice. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.